70-00-8 MSDS - Trifluridine
Online Database of Chemicals Bookmark and Share English Deutsch 한국어

MSDS-CAS.COM / Home >> Chemical Database >> 70-00-8
 




Trifluridine

Identification
Name Trifluridine
CAS Registry Number 70-00-8
Synonyms TFT;TRIFLUORO-D-THYMIDINE;TRIFLURIDINE;TRIFLUOROTHYMIDINE;TRIFLUOROTHYMINE DEOXYRIBOSIDE;2,4(1h,3h)-pyrimidinedione,1-(2-deoxy-beta-d-ribofuranosyl)-5-(trifluorometh;2’-deoxy-5-(trifluoromethyl)-uridin;5-(trifluoromethyl)deoxyuridine
Molecular Structure Trifluridine   70-00-8
Molecular Formula C10H11F3N2O5
Molecular Weight 296.2
mp: 190-193 ℃(lit.)
Hazard Codes: Details
Risk Statements: 20/21/22-40
Safety Statements: 22-36
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
70-00-8.pdf
Trifluridine
Trifluridine structure.svg
Clinical data
Trade names Viroptic; Lonsurf (+tipiracil)
AHFS/Drugs.com Monograph
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Eye drops; tablets (+tipiracil)
ATC code
  • S01AD02 (WHO)
Legal status
Legal status
  • CA: ℞-only
  • US: ℞-only
Pharmacokinetic data
Bioavailability Negligible (eye drops);
≥57% (oral)
Protein binding >96%
Metabolism Thymidine phosphorylase
Biological half-life 12 minutes (eye drops);
1.4–2.1 hrs (combination with tipiracil)
Excretion Mostly via urine
Identifiers
Synonyms α,α,α-trifluorothymidine; 5-trifluromethyl-2′-deoxyuridine; FTD5-trifluoro-2′-deoxythymidine; TFT; CF3dUrd; FTD; F3TDR; F3Thd
CAS Number
  • 70-00-8 YesY
PubChem CID
  • 6256
DrugBank
  • DB00432 YesY
ChemSpider
  • 6020 YesY
UNII
  • RMW9V5RW38
KEGG
  • D00391 YesY
ChEBI
  • CHEBI:75179 N
ChEMBL
  • CHEMBL1129 YesY
ECHA InfoCard 100.000.657
Chemical and physical data
Formula C10H11F3N2O5
Molar mass 296.2 g/mol
3D model (JSmol)
  • Interactive image
 NYesY (what is this?)  (verify)

Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name Viroptic by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals.

Trifluridine was approved for medical use in 1980.[1] It is also a component of the anti-cancer drug trifluridine/tipiracil, which is taken by mouth.


 







Mephenoxalone 70-07-5
6-CHLORO-1,2-BENZISOTHIAZOL-3(2H)-ONE 70-10-0
2-Bromoacetophenone 70-11-1
THIAMINE HYDROCHLORIDE 70-16-6
Glutathione 70-18-8
TETRAHYDROFURFURYL NICOTINATE 70-19-9
OXOTREMORINE 70-22-4
Ethyl bromopyruvate 70-23-5
1-Methyl-3-nitro-1-nitrosoguanidine 70-25-7
L-Ornithine 70-26-8

Content Disclaimer | About | Contact us| Ads

©  MSDS-CAS. All rights reserved.